灯盏花素抗凝血作用的研究  

Study on Effects of Erigeron breviscapus Extract on Anticoagulation

作　　者：王影[1] 杨祥良[1] 刘宏[1] 唐晓荞[1] 

机构地区：[1]华中科技大学药物研究所,武汉430074

出　　处：《中药材》2003年第9期656-658,共3页Journal of Chinese Medicinal Materials

摘　　要：目的 :研究灯盏花素的抗凝血作用。方法 :通过测定凝血时间 (CT)、凝血酶原时间 (PT)、血小板第 3因子 (PF3 )和优球蛋白溶解时间 (ELT) ,从抗凝机制的不同角度研究灯盏花素的抗凝作用。结果 :灯盏花素能显著延长CT、PT ,抑制PF3 活性 ,缩短ELT。结论 :灯盏花素的抗凝血作用是通过影响PF3 和凝血因子V而实现的 ,并能显著提高纤溶活性。Objective: To study the effect of Erigeron breviscapus extract on anticoagulation. Method: Coagulaton time (CT), prothrombin time (PT), platelet factor Ⅲ (PF 3) and euglobulin lysis time (ELT) have been used to evaluate the anticoagulation activities of Erigeron breviscapus extract. Result: Erigeron breviscapus extract significantly delayed CT and PT, inhibited the activity of PF 3, and decreased ELT. Conclusion: Erigeron breviscapus extract plays an role in anticoagulation by inhibiting PF 3 and prothrombin V. It can also enhance the activity of fibrimolysis.

关 键 词：灯盏花素 抗凝血作用 凝血时间 凝血酶原时间 血小板第3因子 优球蛋白溶解时间 

分 类 号：R285.5[医药卫生—中药学]