表皮干细胞增殖与分化的分子调控研究进展  

Regulation of the epidermal stem cell proliferation and differentiation:a research progress

作　　者：林京玉[1] 丁日高[1] 应翔宇[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《军事医学科学院院刊》2003年第4期308-311,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：本文对表皮干细胞增殖与分化的分子调控重要进展进行了综述 ,提示通过干预整合素家族的作用、Wnt信号转导通路、Notch信号转导通路以及c_Myc和p6 3基因的表达等途径 ,可以控制表皮干细胞命运。这些生物技术的实现将给表皮干细胞在基因治疗、组织工程皮肤构建等方面的应用带来十分诱人的前景。The recent studies on the factors that regulate the proliferation and differentiation of the epidermal stem cells are reviewed,indicating that the fate of the epidermal stem cells can be regulated precisely by artificial modification of the signal transduction pathway such as the integrin signal pathway, the Wnt and the Notch signal pathways, and the gene expression such as the c_Myc and the p63, and that the realization and application of this kind of high_techs might bring an attractive prospect for the epidermal stem cells to be successfully used in the field of gene therapy as well as tissue engineering skin manufacturing. [

关 键 词：表皮干细胞 细胞增殖 细胞分化 调控 皮肤 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]