家鸽左心室流出道电生理特性的观察  

The Study of the Electro-physiological Characters of the Left Ventricular Outflo wtract in pigeons

作　　者：焦宏[1] 陈彦静[1] 马建伟[1] 

机构地区：[1]张家口医学院生理教研室,075000

出　　处：《张家口医学院学报》2003年第5期27-29,共3页

基　　金：河北省自然基金资助项目NO:30 0 379

摘　　要：目的 :探讨 4-AP对家鸽左心室流出道组织动作电位的影响。方法 :利用细胞内微电极记录技术 ,观察 1 2例家鸽左心室流出道组织的电生理特征 ,以分析 4 -AP对家鸽左心室流出道的作用。结果 :在局部组织记录到典型的慢反应动作电位 ;用 2mmol/L 4 -AP灌流后 ,慢反应电位RP、APA、Vmax均明显下降 (P <0 .0 5) ,而APD、APD90 也显著延长 ;APD50 无明显改变 (P >0 .0 5)。结论 :家鸽左心室流出道组织不同于普通心室肌组织 ;Objective: To study the effect of 4-AP on the le ft ventricular outflo w tract in pigeons. Methods: Intracellar microelectrode record t echnology was ap plied to observe the electro-physiological characters of the tissues in the left ventricular outflow tract in 12 cases of isolated pigeons,in order to study th e effect of 4-AP. Results: typical slow action potential was re corded in local tissues .After admistrated by 2mmol/L 4-AP, the RP,APA,Vmax obviously decreased (P<0.05),but the APD and APD90 were prolonged significantly. The APD50 had no si gnificant change(P>0.05). Conclusion: The tissue s of the left ventricular outflo w tract of pigeons are different from the typical ventricular tissues. It appear s that 4-AP can inhibit the repolarizing and depolarizing current of the tissues of the left ventricular outflow tract of pigeons.

关 键 词：4一AP 左心室流出道 电生理 慢反应电位 家鸽 组织动作电位 细胞内微电极记录技术 复极离子流 

分 类 号：S852.2[农业科学—基础兽医学]