左心辅助对犬右心室的影响  

Effects of Left Heart Support on Right Ventricle of Dog

作　　者：曹向戎[1] 陈宝田[1] 周晔[1] 

机构地区：[1]首都医科大学附属北京安贞医院心脏外科,100029

出　　处：《北京生物医学工程》2003年第3期210-211,共2页Beijing Biomedical Engineering

摘　　要：目的 :观察左心辅助对犬右心室的影响。方法 :2 1条健康犬按不同左心辅助流量随机分为 3组 ,每组 7条。Ⅰ组辅助流量为 5 0ml·kg- 1 ·min- 1 ;Ⅱ组辅助流量为 70ml·kg- 1 ·min- 1 ;Ⅲ组辅助流量为 90ml·kg- 1 ·min- 1 。应用气动左心辅助装置行左心房至升主动脉辅助 5h。观察辅助前 ,辅助 5h ,停辅助 10min等时间位点的右心血流动力学变化。结果 :辅助 5h ,Ⅰ、Ⅱ、Ⅲ组左房压 (LAP) ,平均肺动脉压 (MPAP) ,全肺阻力 (TPR) ,右室最大压力上升速率 (Rvdp dtmax)均较辅助前明显减小 (P <0 0 5 ) ,且辅助流量越大下降幅度越明显 (P <0 0 5 ) ,Ⅰ、Ⅱ组右心排血指数 (PCI)较辅助前明显增高 (P <0 0 5 ) ,Ⅲ组无明显变化 (P >0 0 5 ) ,Ⅰ、Ⅱ组右心搏动指数 (RCWI)无明显变化 (P >0 0 5 ) ,Ⅲ组明显减小 (P <0 0 5 ) ,停辅助 10min时各组右心血流动力学指标均恢复至辅助前 (P >0 0 5 )。结论 :左心辅助流量越大对右心血流动力学影响越明显 。Aims\ To investigate the effects of left heart support on right ventricle.Methods\ Twenty one dogs were divided into 3 groups for different support flows:group Ⅰ(50ml\5kg -1 \5min -1 , n =7),group Ⅱ(70ml\5kg -1 \5min -1 n =7),group Ⅲ(90ml\5kg -1 \5min -1 n =7).Left heart support with a pneumatic diaphragm\|type (left ventricular support device) was carried out for 5 hours from left atrial to ascending aortic artery bypass.Hemodynamic data were taken at different times.Results\ LAP,MPAP,TPR and Rvdp/dt max after 5 hours' left heart support were lower significantly than the data beofre support for all groups( P <0 05),and their changes were more obvious with increasing of the support flow( P <0 05).RCI were higher for groups Ⅰ,Ⅱ( P <0 05),and there were no significant changes for group Ⅲ( P >0 05).RCWI did not change significantly for groups Ⅰ,Ⅱ( P >0 05),but were lower for group Ⅲ.All hemodynamic data,after the support was stopped for 10 minutes,shows no difference compared to the data before support.Conclusion\ The more was the left heart support flow rate,the more were the changes of right heart hemodynamics.Short period left heart support will not lead to deterioration of function of right heart.

关 键 词：左心辅助 犬 右心室 右心功能 辅助流量 血流动力学 

分 类 号：R54[医药卫生—心血管疾病] R446.11[医药卫生—内科学]