聚乳酸/壳聚糖多孔支架材料的生物学性能评价  

Preparation and Biological Evaluation of PLA/Chitosan Composite Materials

作　　者：李立华[1] 丁珊[1] 周长忍[1] 

机构地区：[1]暨南大学生命科技学院生物材料研究室,广州510630

出　　处：《生物医学工程学杂志》2003年第3期398-400,共3页Journal of Biomedical Engineering

基　　金：国家"973"资助项目 (G19990 5 43 0 6);"863"资助项目(2 0 0 1AA62 5 0 5 0 );广东省"十五"重大专项资助项目 (A3 0 2 0 2 0 10 4)

摘　　要：通过过敏试验、热原试验和细胞培养与毒性试验 ,对聚乳酸 (PL A) /壳聚糖多孔支架材料进行了生物学评价。结果显示 ,聚乳酸 /壳聚糖复合三维多孔材料均呈阴性 ,符合 ISO10 993- 1标准 ,细胞能在材料表面更好的贴附和生长。所以 ,本材料具有良好的生物相容性 ,可以用作细胞支架材料植入体内。Hypersusceptibility test, pyrogen test, cell cultivation, and toxicity examination were applied in the biological evaluation of the polylatic acid (PLA)/chitosan composite materials. The results indicated that all the materials were negative, conforming to the ISO10993-1. The cell could grow well on the surface of the materials. So the PLA/chitosan composite materials have good biocompatibility and can be planted in the body as scaffolds.

关 键 词：聚乳酸 壳聚糖 多孔支架材料 生物学 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]