聚乙烯醇/羟基磷灰石复合水凝胶软骨植入材料的研究  

Studies of Poly(vinyl alcohol)/Hydroxylapatite Hydrogels Compounds for Cartilage Implantation

作　　者：郑裕东[1] 王迎军[1] 陈晓峰[1] 刘青[1] 卢艺[1] 

机构地区：[1]华南理工大学材料学院,广州510640

出　　处：《生物医学工程学杂志》2003年第3期401-403,465,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金重点资助项目 (5 993 2 0 5 0 ) ;广东省自然科学基金资助项目 (990 62 1) ;广东省十五重大科技攻关资助项目(A3 0 2 0 2 0 2 0 2 )

摘　　要：研究了用于人工关节软骨假体的聚乙烯醇水凝胶和羟基磷灰石复合材料的结构与性能 ,系统讨论了含水量、羟基磷灰石含量等对其拉伸强度 ,压缩强度 ,黏弹性、润滑性等生物力学性能的影响 ,观察和比较了复合材料的微观形貌。研究表明羟基磷灰石在聚乙烯醇水凝胶中分散均匀 ,良好相容 ,使复合材料的力学强度和润滑性能提高。The structures and properties of polyvinyl alcohol (PVA)/ hydroxylapatite (HA) composites were investigated. The components and processing conditions were studied for preparation of optimum compound hydrogels with good lubricating feature and high bioactivity. The properties such as stretch strength, compressive strength, friction and compressive stress relaxation of various compound hydrogels were compared. The micro-morphology of PVA hydrogels and PVA/HA hydrogels were investigated by SEM. It was found that the addition of HA can improve the lubricating feature and mechanical strength of hydrogels, and its compressive stress relaxation properties were closer to that of natural cartilages.

关 键 词：聚乙烯醇 羟基磷灰石 复合材料 水凝胶 生物材料 人工软骨植入 

分 类 号：R318.08[医药卫生—生物医学工程] R318.17[医药卫生—基础医学]