238例复治肺结核病人耐药状况分析  

Analysis of drug resistance in 238 retreated smear-positive and sputum-culture-positive pulmonary tuberculosis cases

作　　者：周丽平[1] 李国明[1] 刘勋[1] 李爱国[1] 

机构地区：[1]湖北省疾病预防控制中心传染病防治研究所结核病预防控制部,武汉市430079

出　　处：《中国热带医学》2003年第6期756-757,共2页China Tropical Medicine

摘　　要：目的　了解复治肺结核病人形成原因和耐药状况 ,分析结核病控制策略的效果。　方法　分析 1999年湖北省耐药监测入选 2 3 8例复治涂阳培阳病例既往病史和耐药状况 ;药敏试验采用比例法 ,培养基中药物浓度分别为S4μg ml、H 0 2 μg ml、R 40 μg ml和E 2 μg ml;　结果　总耐药率为 44 5 % ,耐多药率为 2 1 8% ,在综合医院、乡镇卫生院和结防专业机构治疗造成的耐药率和耐多药率 (含H和R)分别为 5 6 4%、3 1 3 %、46 3 %和 3 0 8%、15 0 %、2 0 8%。　结论　治疗不规范是导致耐药率和耐多药率升高的原因 ,建议加强结核病人归口、化疗和全程督导管理 ,进一步完善结核病控制策略 ,减少复治病例和耐药的产生。Objective To understand drug resistance status and cause in pulmonary tuberculosis patients retreated and evaluate the results of tuberculosis control strategy Methods The history of hospitalization and drug resistance of 238 retreated smear-positive and culture-positive pulmonary tuberculosis patients were analyzed in Hubei Province in 1999 Drug sensitivity tests with proportion methods had been conducted with the drug concentrations:SM μg4/ml,INH 0 2μg/ml,RFP 40μg/ml EMB 2μg/ml Results The total drug resistant rate was 44 5% and the multidrug resistant rate was 21 8% The rates of drug resistance and multidrug resistance in integrated hospitals,township hospitals and tuberculosis control organizations were 56 4%,31 3%,46 3% and 30 8%,15 0% and 20 8% Conclusion Irregular treatment of tuberculosis patients has been the main cause for the occurrence of drug resistance and mulatidrug resistance in the tuberculosis patients treated

关 键 词：复治 肺结核 耐药性 治疗 

分 类 号：R521[医药卫生—内科学]