原发性肾病综合征与狼疮性肾病尿微量蛋白类型和含量分析  

Analysis of type and content of urinary albumin in the urine of primary renal syndrome and lupus nephritis patients

作　　者：段力平[1] 陈寒超[1] 邱平[1] 王庆秋[1] 符育群[1] 

机构地区：[1]海南省海口市人民医院,海口市570208

出　　处：《中国热带医学》2003年第6期771-772,共2页China Tropical Medicine

摘　　要：目的　探讨原发性肾病综合征和狼疮性肾病尿微量蛋白类型和含量的临床价值。　方法　用放射免疫方法分别测定原发性肾病综合征组 2 6例、狼疮性肾病组 2 4例和对照组 (健康者 ) 3 0例的尿微量白蛋白 (μ AIb)、尿IgG(μ -IgG)、尿 β2 -微球蛋白 (β2 -MG)、尿α1 -微球蛋白 (α1 -MG)、血Tamm -Horsfall糖蛋白 (THP)和血 β2 -MG水平。　结果　两组肾病患者 μ -AIb、μ -IgG、尿 β2 -MG、尿α1 -MG水平均较正常对照组显著升高 (P <0 0 1) ;两组患者则差异无显著性 (P >0 0 5 ) ;μ -AIb、μ -IgG、尿α1 -MG三者呈相关 (P <0 0 5 ) ,与尿 β2 -MG无相关。　结论　尿微量蛋白类型和含量不能作为区别原发性肾病综合征与狼疮性肾病的依据 ;两种肾病均有不同程度的肾小球和肾小管的双重损害 ,尿微量蛋白类型和含量与肾小球和肾小管病理损害一致 ;肾病综合征患者早期动态监测尿微量蛋白类型和含量 。Objective To investigate the clinical significance of type and content of urinary albumin in the urine of primary renal syndrome and lupus nephritis patients Methods The concentrations of urinary albumin (μ-aIb)?immunoglobulin G(μ-IgG)?β 2-microglobulin(β 2-MG),α 1-microglobulin(α 1-MG),in 26 primary nephritic syndrome patients,24 lupus nephritic patients and 30 healthy subjects were detected by radioimmunoassay Results The results show that the concentrations of μ-aIb?μ-IgG?β 2-MG and α 1-MG in primary nephritic syndrome and lupus nephritis patients markedly increased (P<0 01) than those in the healthy subjects There were no significant differences between the two groups of primary nephritic syndrome and lupus nephritis patients(P>0 05) Conclusion The levels of μ-aIb?μ-IgG?β 2-MG and α 1-MG may be the laboratory parameters and can not be taken as the basis for differentiation of primary nephritic syndrome patients from lupus nephritis patients

关 键 词：原发性肾病综合征 狼疮性肾病 尿微量蛋白 类型 含量 

分 类 号：R593.242[医药卫生—内科学]