β_2受体激动剂盐酸班布特罗治疗高原地区COPD和高原肺心病疗效观察  

EFFECT OF LONG - ACTING β_2 - AGONISTS BAMBUTEROL ON PATIENTS WITH COPD AND COR PULMONAL AT HIGH ALTITUDE

作　　者：顾玉海[1] 张月琴[1] 多杰[1] 赵华[1] 赵俊[1] 妥亚军[1] 

机构地区：[1]青海省人民医院呼吸科,810007

出　　处：《高原医学杂志》2003年第3期15-17,共3页Journal of High Altitude Medicine

摘　　要：目的:观察β2受体激动剂班布特罗治疗高原地区慢性阻塞性肺病(COPD)和高原肺心病疗效;方法:对来自2 200m～3 600m 84例高原COPD和肺心病患者给予班布特罗20mg每日一次口服,疗程为2周,并观察给药前后肺功能及血气分析指标的变化;结果:治疗后,肺功能指标(VC、FEV1.0、PEF、FEF50％)及动脉血气指标(PaO2、PaCO2、SatO2)较治疗前均有明显的改善(P<0.05,P<0.001);结论:班布特罗具有较强的支气管扩张作用,能降低气道反应性,改善通气量,提高血氧分压,改善缺氧,作用时间长,副作用较少,是临床治疗支气管痉挛迅速而有效的较好药物。Objective: To discuss effects of β2 - agonist Bambuterol on 84 patients with COPD and cor pul-monale at high altitude. Methods: 20mg Bambuterol was taken by each patient coming from the area (2 260m-3 600m). Duration was 2 weeks. Results:Each patient carried out pulmonary function test (VC, FVC, FEV1.0, PEF and FEF50%) and blood gas analysis (PaO2, PaCO2 and SatO2) before and after treatment. Conclusion: Bambuterol had a strong and long brochiectasis ,and dreased high reaction of the airway, and improved ventilation reverse, enhance PaO2 and improve lake of oxygen as well. It had features of long time action and a few side effect. It is a better drug to treat brochospasy quickly and effectively.

关 键 词：盐酸班布特罗 Β2受体激动剂 慢阻肺肺心病 高原 

分 类 号：R563.9[医药卫生—呼吸系统] R541.5[医药卫生—内科学]