男性血清生物有效性睾酮与心血管病危险因素个体聚集性的相关性现况调查  

Correlations between serum bioavailable testosterone and the clustering of cardiovascular disease risk factor in men:a cross-sectional study

作　　者：谭家余[1] 吴赛珠[2] 黄汉卿[1] 郭峰[1] 杨彩[1] 陈一伟[1] 吴迎星[3] 

机构地区：[1]兰州军区总医院老年病科 [2]南方医院心内科 [3]中国人民解放军61517部队门诊部

出　　处：《中华老年多器官疾病杂志》2003年第3期192-195,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家重点基础研究发展规划"973"资助项目(G200057008);国家自然科学基金(39600169)

摘　　要：目的 通过分析男性血清生物有效性睾酮(Bio-T)与心血管病危险因素个体聚集性的相关性,探讨Bio-T在冠心病发病中的地位。方法 通过现况调查,以1546例男性为研究对象,用放射免疫法测定血清Bio-T,并检测体重指数、血脂谱、血压、血糖等。结果 按Bio-T四分位进行分层(3.54,5.06,8.03 nmol/L)分析结果显示男性BMI,SBP,DBP,TC,LDL-C和SG均随Bio-T浓度的下降明显升高,而HDL-C随Bio-T浓度的下降则明显降低。以心血管病危险因素聚集为因变量,Bio-T四等分组设亚变量,调整年龄、吸烟、饮酒、进行logistic回归分析,结果显示随着Bio-T水平的下降,两个以上心血管病危险因素聚集的危险性升高。结论 男性Bio-T可能是心血管病危险因素聚集的原因之一,雄激素水平的变化与冠心病发病密切相关。Objective In order to investigate the importance of bioavailable testosterone (Bio-T) in the occurrence of coronary heart disease, the correlation between Bio-T and clustering of cardiovascular disease risk factor (CCDRF) was studied. Methods In a cross-sectional study, 1 546 male volunteers, including the resigned and retired cadres of Chinese PLA and some of their dependents participated. Bio-T was measured by radioimmunoassay (RIA). Body mass index, lipids, blood pressure and blood sugar were measured. Results The data showed that the levels of BMI,SBP,DBP,TC, LDL-C and SG increased obviously with the decrease in the serum concentration of Bio-T according to stratification of the quartile of Bio-T(3.54,5.06,8.03 nmol/L), but the level of HDL-C was reverse. After adjusting age, sex, smoking and drinking, there was dose-response relationship between Bio -T and the clustering of cardiovascular disease risk factor in men. Conclusion Bio-T may be one of the reasons that lead to the clustering of cardiovascular disease risk factors in men. There is a close correlation between the change in Bio-T and the occurrence of CHD.

关 键 词：男性 血清 生物有效性睾酮 心血管病 调查 危险因素聚集 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]