智能搜索用于实际样品的液相色谱分离条件的优化  

The Optimization of the High Performance Liquid Chromatographic Conditions for Actual Samples Using an Intelligent Search Method ,

作　　者：黄红心[1] 张玉奎[1] 林从敬[1] 卢佩章[1] 

机构地区：[1]中国科学院大连化学物理研究所国家色谱研究分析中心,116012

出　　处：《色谱》1992年第3期125-128,共4页Chinese Journal of Chromatography

摘　　要：本文提出了可用于色谱操作条件自动优化的串形优化指标和智能搜索法。串形优化指标可正确地评价一张色谱图的质量,而智能搜索法把宽度优先和深度优先的原理及单纯形中多种逻辑算法相结合而进行色潜操作条件的最优化。实验表明:该法用于水溶性维生素及芳烃化合物的优化可获得满意的结果。To represent the hierarchical relationship between the optimization criterion and the parameters to be determined, a multifactor hierarchical chromatographic optimization response function (HCRF) and intelligent search method have been established. Width-first and depth-first search strategy and the local algorithms are incorporated into the intelligent search method. It has been shown experimentally that the results of optimization for water-soluble vitamins and aromatic compounds are satisfied.

关 键 词：液相色谱 分离条件 自动优化 

分 类 号：O657.72[理学—分析化学]