Follicular growth,differentiation and atresia  

作　　者：JIN Xuan & LIU Yixun State Key Laboratory of Reproductive Biololgy, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China 

出　　处：《Chinese Science Bulletin》2003年第17期1786-1790,共5页

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.30170452,39970284 and 90208025);the State“973”Program(Grant No.G1999055901);the Knowledge Innovation Project of the Chinese Academy of Sciences(Grant No.KSCX-SW-201).

摘　　要：Only limited numbers of primordial follicles in mammalian ovary grow and differentiate to reach the stage of dominate follicles and ovulate. 99% of the follicles in the ovary undergo atresia at various stages of development. Regulation of follicular growth, development and atresia is a complex process and involves interactions between endocrine factors and intraovarian regulators. This review summa-rized:ⅰ) FSH may not be a survival factor in regulating slow-growing preantral follicles. Some locally produced growth factors, activin and orphan receptors might play a more important role at this stage. ⅱ) Estrogen, activin/ inhibin and follistatin coordinate with FSH to regulate and control follicle differentiation. ⅲ) There are two types of follicular atresia induced by apoptosis which originates from GC or oocyte, respectively. Early translation of tPA mRNA into tPA protein in oocyte may be associated with oocyte apoptosis.Only limited numbers of primordial follicles in mammalian ovary grow and differentiate to reach the stage of dominate follicles and ovulate. 99% of the follicles in the ovary undergo atresia at various stages of development. Regulation of follicular growth, development and atresia is a complex process and involves interactions between endocrine factors and intraovarian regulators. This review summa-rized:ⅰ) FSH may not be a survival factor in regulating slow-growing preantral follicles. Some locally produced growth factors, activin and orphan receptors might play a more important role at this stage. ⅱ) Estrogen, activin/ inhibin and follistatin coordinate with FSH to regulate and control follicle differentiation. ⅲ) There are two types of follicular atresia induced by apoptosis which originates from GC or oocyte, respectively. Early translation of tPA mRNA into tPA protein in oocyte may be associated with oocyte apoptosis.

关 键 词：哺乳动物 原始卵泡 卵泡生长 粒状细胞 细胞分化 

分 类 号：Q954.4[生物学—动物学]