基因治疗与组织工程在运动医学中的应用  

The Application of Gene Therapy and Tissue Engineering

作　　者：柯杰兵[1] 林建棣[1] 屈联国[1] 李爽[1] 

机构地区：[1]解放军体育学院,广东广州510500

出　　处：《解放军体育学院学报》2003年第4期96-99,共4页

摘　　要：在过去的 2 0年里 ,因为康复手段的进步、新的外科手术的出现以及生物力学研究的进展 ,使运动损伤的治疗方法得到了很大的丰富。但尽管如此 ,目前对前后十字韧带断裂、内侧半月板损伤、软骨损伤以及延迟性骨折等的治愈能力还是很有限的。人们正在寻找新的生物学方法 (如生长因子 )来加快对这些损伤的治疗进程。用转移特定基因 (如编码生长因子 )的基因治疗手段将治疗蛋白植入损伤组织是治疗这些损伤较有前景的途径。组织工程与基因治疗相结合 ,在促进各种受损组织的再生与修复方面将具有很大的潜力。Treatment of sports injuries has improved through sophisticated rehabilitation programs, novel operative techniques, and advances in biomechanical research during the past two decades. Despite considerable progress, treatments remain limited due to poor healing capacity for anterior or posterior cruciate ligament rupture, central meniscal tear, cartilage lesions, and delayed bone fracture. New biological approaches seek to treat these injuries with growth factors to stimulate and hasten the healing process. Gene therapy using the transfer of defined genes such as those encoding growth factors represents a promising way to deliver therapeutic proteins to the injured tissue. Tissue engineering, which may eventually be combined with gene therapy, offers the potential to create tissues or scaffolds for regeneration of defects occurring from trauma.

关 键 词：基因治疗 组织工程 运动损伤 

分 类 号：G804.5[文化科学—运动人体科学]