黄芪增免散对围手术期食管癌间质反应与免疫调节机制探讨  

Mechanism explore of interstitial response and the immune regulation of Huangqi zengiman Powder on the patients with esophageal cancer at peri-operation period

作　　者：高新平[1] 杨廷桐[1] 任金平[1] 赵卫星[1] 李汉臣[2] 刘彩莉[2] 

机构地区：[1]新乡医学院病理学教研室,河南新乡453003 [2]新乡医学院第一附属医院,河南卫辉453100

出　　处：《中成药》2003年第10期812-814,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :观察黄芪增免散 (黄芪 ,女贞子 ,枸杞子 ,肉苁蓉 ,红参等 )对围手术期食管癌患者免疫功能和肿瘤局部组织的影响。方法 :用黄芪增免散治疗围手术期食管癌患者 37例 ,共 4周。采用APAAP法检测治疗前后外周血T淋巴细胞数量及分类 ;对手术切除标本 ,采用甲苯胺蓝和S 10 0蛋白ABC免疫组化染色法观察治疗后癌组织内 (包括Langerhans细胞、肥大细胞、微血管、淋巴细胞等 )变化 ,并与同期手术治疗的 14例患者作对照。结果 :治疗组外周血T淋巴细胞数量及T4/T8、癌组织内Langerhans细胞、肥大细胞数量及微血管损伤明显均高于对照组 (P <0 .0 5 )。结论Objective: To observe the effect of Huangqizengmian Powder (HQZMP) (Radix Astragali, Fructus Ligustri Lucidi, Fructus Lycii, Herba Cistanches, Radix Ginseng Rubra, etc.) on the immune function and interstitial response of the patients with esophageal cancer at peri operational period. Methods: Thirty seven patients with esophageal cancer were treated with HQZMP for 4 weeks peri operationally. The quantity and classification of T lymphocytes in the patients' peripheral blood was detected using APAAP immunoassay before and after the treatment, and the pathological tissue changes (including Langerhans cells、mastocyte、lymphocytic and microvessels response) in resected esophageal cancer sample were observed using S 100 protein ABC immunohistochemical and toluidine blue stain. 14 patients as control group weren't treated with HQZMP. Results: As compared with the control group, the quantity of T lymphocyte in patients' peripheral blood and T4/T8、Langerhans cell、mastocyte and microvessel damage in the tissues were more obvious in the HQZMP treated group ( P < 0.05 ). Conclusion: HQZMP could improve the whole and local tissue immune function of the esophageal cancer patients in peri operational period.

关 键 词：黄芪增免散 免疫功能 食管癌 微血管 

分 类 号：R287[医药卫生—中药学]