壳聚糖-羧甲基壳聚糖膜的生物相容性研究  

Biocompatibility of Chitosan-Carboxymethylchitosan as Membrane for Periodontal Guided Tissue Regeneration

作　　者：庄昭霞[1] 林志勇[2] 曹金芳[1] 

机构地区：[1]山东大学口腔医院牙周科,山东济南250012 [2]山东省立医院口腔内科,山东济南250021

出　　处：《上海口腔医学》2003年第5期362-365,共4页Shanghai Journal of Stomatology

基　　金：山东省自然科学基金(Y98C09038)

摘　　要：目的观察壳聚糖-羧甲基壳聚糖作为牙周引导组织再生膜的生物相容性。方法采用冷冻干燥法制备壳聚糖-羧甲基壳聚糖膜,然后通过细胞毒性试验、肌内植入试验等体内外生物学试验相结合的方法研究其生物相容性。结果测试表明,壳聚糖-羧甲基壳聚糖膜无毒,膜植入早期出现巨噬细胞为主的炎症反应;随着膜的降解,炎症反应逐渐减轻,周围组织无不良反应。结论壳聚糖-羧甲基壳聚糖膜具有良好的生物相容性。Objective To investigate the biocompatibility of chitosan-carboxymethylchitosan as membrane for periodontal guided tissue regeneration(GTR).Methods Chitosan-carboxymethylchitosan blending membrane was prepared by freeze-drying and tests including cytotoxicity test,inserting the membrane into the rabbits ,muscles,were employed to investigate its biocompatibility.Results Chitosan-carboxymethylchitosan blending membrane showed no toxicity.In early period after the insertion of the membrane,inflammatory processes with macrophages were observed,but the processes reduced with the membrane degradation.Conclusion Chitosan-carboxymethylchitosan blending membrane has desirable biocompatibility.

关 键 词：壳聚糖 羧甲基壳聚糖 生物相容性 引导组织再生 

分 类 号：R318.08[医药卫生—生物医学工程]