老年冠状动脉粥样硬化性心脏病亚临床期高密度脂蛋白的变化  

The changes of high-density lipoprotein in subclinical stage of the elderly patients with coronary heart disease

作　　者：刘芳[1] 王一尘[1] 袁惠敏[1] 宓继红[1] 渠胜英[1] 张江蓉[1] 

机构地区：[1]上海第二医科大学附属新华医院老年科,上海200092

出　　处：《中国综合临床》2003年第10期887-888,共2页Clinical Medicine of China

基　　金：上海市卫生局课题 (课题编号 :No .994L14 )

摘　　要：目的分析老年冠状动脉粥样硬化性心脏病 (冠心病 )患者亚临床期高密度脂蛋白 (HDL)的变化 ,为冠心病的预防提供依据。方法随机选取冠心病者 (研究组 )和非冠心病者 (对照组 )各 30 0例 ,分析冠心病患者在确诊当年及前 4年的HDL变化 ,并与对照组比较。结果冠心病组确诊前 1年HDL(1 .39± 0 .34)mmol/L ,明显低于非冠心病组 (1 .50± 0 .52 )mmol/L(P <0 .0 1 ) ;冠心病组诊断当年及前 4年的HDL变化曲线显示 :在诊断前 1年HDL处于最低谷 ,而在诊断当年HDL明显升高。结论HDL与冠心病的发生密切相关。HDL在冠心病明确诊断前 1年最低 ,诊断的当年最高 ,且呈上升趋势 。Objective To analyze the changes of high-density lipoprotein( HDL) in subclinical stage of the elderly with coronary heart disease(CHD) for pr oviding the clinical basis of preventing CHD. Methods 300 CHD pa tients(research group) and 300 non-CHD patients(control group) were randomly se lected to analyze the changes of HDL on diagnosis and 4 years before diagnosis. The comparison was then made between the two groups. Results H DL in CHD group at 1 year before diagnosis was remarkably lower than that in non -CHD group(1.39±0.34 and 1.50±0.52, P<0.01).The change curve of HDL in CHD group on diagnosis and at 4 year before diagnosis showed that HD L was at the lowest level 1 year before diagnosis while increased at the year of diagnosis. Conclusion HDL is closely related with CHD, which is at the lowest level 1 year before diagnosis and at the highest level at the yea r of diagnosis in an increasing trend, so the measurement of intervene of lipopr otein is extraordinarily necessary.

关 键 词：冠状动脉疾病 高密度脂蛋白 老年人 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]