良性增生前列腺组织上皮和间质细胞雄激素受体测定  

ANDROGEN RECEPTOR IN STROMA AND EPITHELIUM OF NORMAL AND HYPERPLASTIC HUMAN PROSTATES

作　　者：陈青[1] 林毓琴[1] 

机构地区：[1]山东医科大学生物化学教研室

出　　处：《山东医科大学学报》1992年第3期181-185,共5页Acta Academiae Medicinae Shandong

基　　金：国家自然科学基金资助项目(39070880)

摘　　要：用~3H-Mibolerone为放射性配体,分别测定了正常人(n=8)及良性增生(n=20)前列腺上皮、间质细胞雄激素受体(AR),结果表明,AR含量以fmol/mgDNA表示时,正常前列腺组织上皮、间质部分分别为352.3±150.9和728.7±369.4;良性前列腺增生(BPH)组织上皮、间质部分分别为358.0±161.8和471.9±254.0,经统计学处理,AR在BPH及正常前列腺组织上皮、间质部分之间差异无显著性,表明AR在前列腺组织中的分布和含量与BPH的发病无直接关系。Using radioreceptorassay,we measured the concentration of AR in mechenically separated stroma and epithelium from 8 case of normal and 20 ease of hyperplastic human prostate.The concentration of AR expressed in DNA content of homogenate(fmol/mg DNA),were 352.3±150.0 and 728.7± 369.4 in epithelium and stroma fraction of normal prostate,and 358.0±161.8 and 471.9±254.0 in epithelium and stroma fraction of BPH,retpectively。 No significant difference was found in the concentration of AR between BPH and normal prostate in the stroma and epithelium。The results suggest that the distribution and content of AR in prostate have no direct relationship to the pathogenesis of BPH.

关 键 词：前列腺 受体 雄激素 放射配位体 

分 类 号：R329.26[医药卫生—人体解剖和组织胚胎学]