慢性静脉压增高状态下脑微循环的动态研究  

Hemodynamics of chronic venous hypertension in rat

作　　者：宋振全[1] 魏学忠[1] 

机构地区：[1]沈阳军区总医院神经外科,沈阳110015

出　　处：《中华神经外科杂志》2003年第5期368-371,共4页Chinese Journal of Neurosurgery

摘　　要：目的 研究慢性静脉压增高状态下脑微循环的动态变化。方法 选择Wistar雄性大鼠16只(对照组A n=6;实验组B n=10),全身麻醉下行右侧颈总动脉与右侧颈外静脉端端吻合。利用激光多普勒扫描技术测定吻合前-后以及2周后吻合部结扎前-后脑表25处局部脑血流(ICBF)和局部脑血流量(ICBV)的变化,区域脑血流(rCBF)和区域脑血流量(rCBV)分别用各自的25个数据的中位数表示。A组:单纯右颈总动脉结扎;B组:右颈总动脉与右颈外静脉端端吻合。结果 A组的两侧大脑半球以及B组的左侧大脑半球吻合前后rCBF、rCBV的变化无统计学意义,B组的右侧大脑半球吻合前后rCBF rCBV也无统计学意义,但2周后rCBF显著降低(p<0.05),rCBV显著增高(P<0.05),吻合部结扎后rCBF即刻增高(P<0.05),rCBV即刻降低(P<0.05):结论 一侧颈总动脉-颈外静脉吻合模型对研究慢性静脉压增高状态下脑缺血的研究具有实用价值;在慢性静脉压增高状态下结扎动静脉短路后,脑灌注压迅速上升,CBF得到改善。Objective To evaluated the changes of regional venous flow (rCBF) and cerebral blood volume (rCBV) in chronic venous hypertension model in rat. Method Venous hypertension was induced by an end-to-end anastomosis between the right carotid artery and the right external jugular vein.Local CBF (1CBF) and 1CBV at 25 locations were assessed by a modern laser Doppler 'scanning' technique at 4 times point before and after the fistula.The animals were classified in two groups:group A (n=6) (controued group, the carotid artery occlusion only) and group B (n=10) . Results In group A and the left hemisphere oi group B,both of rCBF and rCBV didn't change.However,in the right hemisphere of group B, rCBV significantly increased 2 weeks after the bypass but recovered after clipping of the fistula (P<0.05) ,and rCBF significantly decreased 2 weeks after the bypass but recovered after clipping of the fistula ( P <0.05) .Conclusion The rat model of carotid -jugular arteriovenous fistula is clinically relevant and useful for studying the pathophysiology of chronic venous hypertension.Venous ischemia is a reversible condition which can be improved by appropriate early-stage treatment.

关 键 词：慢性静脉压增高 脑微循环 全身麻醉 动态研究 大鼠 脑静脉窦闭塞 脑积水 硬脑膜动静脉畸形 

分 类 号：R651[医药卫生—外科学]