慢性阻塞性肺疾病继发肺部真菌感染的临床特征及危险因素  

Risk factors of secondary pulmonary fungal infection of the chronic obstructive pulmonary disease and its clinical features

作　　者：杭建明[1] 李坚[1] 赵夕武[1] 张蓝石[1] 

机构地区：[1]江苏大学附属医院呼吸内科,江苏镇江212001

出　　处：《中国综合临床》2003年第11期981-982,共2页Clinical Medicine of China

摘　　要：目的探讨慢性阻塞性肺疾病 (COPD)继发肺部真菌感染的临床特征及危险因素。方法回顾性分析 32例COPD继发肺部真菌感染患者的临床资料。结果COPD继发肺部真菌感染临床表现无特异性 ,胸部X线表现以支气管肺炎为多见 ,病原菌主要以白色念珠菌为主。广谱高效抗生素、糖皮质激素的应用和低蛋白血症、高龄是继发真菌感染的主要危险因素。结论降低COPD继发真菌感染发病率的主要途径是避免盲目使用高效广谱抗生素及糖皮质激素 ,预防医源性感染 ,增加患者的免疫力。Objective To study the risk factors of secondary pulmonary fungal infection of the chronic obstructive pulmonary disease(COPD) and its clinical features. Methods The clinical data of 32 COPD cases with the secondary pulmonary fungal infection were retrospectively analyzed. Results The clinical manifestations of secondary pulmonary fungal infection of COPD were not specific. X-ray features mainly showed bronchopneumonitis. Candia albicans was ranked as the first pathogen. The risk factors of secondary pulmonary fungal infection of COPD were utilization of broad spectrum antibiotics and corticosteroids, hypoproteinemia and old age. Conclusion The best approach to reduce the incidence rate of secondary pulmonary fungal infection of COPD is to avoid abuse of broad spectrum antibiotics and corticosteroids, to prevent the iatrogentic infection and enhance the immunity of the patients.

关 键 词：慢性阻塞性肺疾病 真菌感染 临床特征 危险因素 

分 类 号：R563.9[医药卫生—呼吸系统]