U-74389G PRETREATMENT ATTENUATING WARM ISCHEMIA INJURY IN LIVER TRANSPLANTATION  

作　　者：严佶祺 李宏为 张明钧 杨卫平 蔡伟耀 林言葳 

机构地区：[1]DepartmentofSurgery,RuijinHjospital,SSMU,Shanghai200025,China

出　　处：《Journal of Shanghai Second Medical University(Foreign Language Edition)》2002年第2期87-90,101,共5页上海第二医科大学学报（英文版）

摘　　要：Objective To investigate the protective role of lazaroid U-74389G pretreatment against warm ischemia injury of rat liver transplantation from non-heart-beating donors. Methods Rat othortopic liver transplantation was perfomed in 4 groups (N-45, N-60, pN-45 and pN-60 ), according to pretreatment with U-74389G or not, and the non-heart-beating time 45rain or 60rain before donor liver harvested. Survival rates, liver functions, MDA values and graft pathology of each group were compared. Results The one-week survival rates of Group N-45, N-60 , pN-45 and pN-60 were25% (2/8), 0% (0/8), 58.3% (7/12) and 33.3% ( 4/12 ), respectively. U-74389G pretreatment significantly increased survival rate of rat liver trans-plantation from non-heart-beating donors, but also improved liver functions and graft pathologies, as well as decreased MDA expression. Conclusion U-74389G pretreatment could attenuate warm ischemia reperfusion injury of rat liver transplantation from non-heart-beating donors.

关 键 词：缺血再灌注损伤 U-74389G 缺血预处理 肝脏移植 

分 类 号：R657.3[医药卫生—外科学]