前列腺素E_1在股骨头缺血性坏死介入治疗中的应用  

A Clinical Study of Interventional Therapy with PGE_1 for the Treatment of the Avascular Necrosis of the Femur Head

作　　者：王德利[1] 阮狄克[1] 李海峰[1] 杨敏杰[2] 刘亚民[2] 

机构地区：[1]海军总医院骨科,北京市100037 [2]西安交通大学医学院数字减影室

出　　处：《骨与关节损伤杂志》2003年第9期593-595,共3页The Journal of Bone and Joint Injury

摘　　要：目的 探讨股骨头缺血坏死的治疗方法及其近期疗效。方法 介入靶血管脉冲式加压药物灌注,31例病人随机分为两组,分别使用扩血管药物及前列腺素E_1,结合临床疗效,复查X线平片、DSA造影等评估。结果 应用前列腺素E_1组患者疗效显著,复查DSA造影,对比相同时相股骨头颈区单位面积血管数目,出现明显增多、延长、部分中断的血管再通。结论 用前列腺素E_1在数字减影下介入治疗股骨头缺血坏死可获得满意疗效,这为股骨头缺血坏死的治疗提供了新的途径。Objective To explore better treatment and quantification of the avascular necrosis of femur head. Methods Thirty-one cases were divided into two groups randomly with interventional therapy, prostaglandin E1 and vessel expanded drug were applied separately. The finding of these patients with X-ray, DSA imaging were evaluated. Results The clinical finding were significantly effective in PGE1 group, comparing with the postoperative DSA imaging, the ratio of blood vessels increasing, elongation and recanalization were significantly high than the control group. Conclusion Interventional therapy with PGE1 aided by DSA imaging can obtain well effect for the avascular necrosis of femur head. A new way of the treatment is offered in this study.

关 键 词：前列腺素E1 股骨头缺血性坏死 介入治疗 应用 

分 类 号：R681.8[医药卫生—骨科学]