氟中毒对大鼠口腔粘膜细胞和肝细胞DNA损伤的影响  

Effects of fluorosis on oral mucosal cell and Hepatocyte DNA damage in rats

作　　者：贺凌飞[1] 陈建刚[1] 

机构地区：[1]武汉大学中南医院口腔科,武汉430071

出　　处：《中国地方病防治》2003年第5期272-274,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：目的 研究氟中毒对大鼠口腔粘膜细胞和肝细胞DNA损伤的影响。方法 雄性SD大鼠饮用含150mg/L氟化钠(NaF)的蒸馏水溶液4周,用单细胞凝胶电泳检测细胞DNA损伤。结果 氟中毒能明显诱导大鼠口腔粘膜细胞和肝细胞DNA损伤,总损伤细胞百分率分别为50.20％和44.80％。结论 氟中毒能引起大鼠口腔粘膜细胞和肝细胞DNA损伤。Objective To study the effects of fluorosis on oral mucosal cell and hepatocyte DNA damage in rats.Methods Two groups of male SD rats were provided with deionized drinking water containing 0( control group) and fluoride(150mg/L sodium fluoride) respectively for 4 weeks. Single cell gel - electrophoresis assay was used to test the DNA damage rate in rat oral mucosal cells and hepa-tocytes.Results The DNA damage rates of fluorosis group were 50.20% in oral mucosal cells and 44.80% in liver cells and were higher than that of the control group significantly. Conclusions The data indicated that fluorosis could induce oral mucosal cell and hepatocyte DNA damage in rats.

关 键 词：氟中毒 大鼠 口腔粘膜细胞 肝细胞 DNA损伤 影响 

分 类 号：R599.9[医药卫生—内科学]