胃炎灵对大鼠胃粘膜保护作用的研究  

Protective Effect of Weiyanling on Gastric Mucosa of Rats

作　　者：曲智威[1] 张冬菊[1] 刘以溥[1] 

机构地区：[1]北华大学医学院附属医院消化内科,吉林市132011

出　　处：《中国中西医结合消化杂志》2003年第5期276-277,共2页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：目的 :探讨胃炎灵对实验大鼠胃粘膜损伤的保护作用及可能机制。方法 :在无水乙醇形成大鼠胃粘膜损伤模型后 ,应用中药胃炎灵治疗并观察胃粘膜病理变化、炎症程度、溃疡指数 (UI)及溃疡面积 ,并检测胃粘膜氨基乙糖及前列腺素 E2 (PGE2 )含量。结果 :治疗组胃粘膜充血、水肿、坏死、炎症程度、UI及溃疡面积较对照组明显减少 (P<0 .0 5 ) ,两组胃粘膜氨基乙糖及 PGE2 对照差异亦有显著性意义 (P<0 .0 5 )。结论 :胃炎灵对胃粘膜有良好的细胞保护作用 ,其机制可能为该药抑制炎症反应 ,提高氨基乙糖含量 ,增加 PGE2 的合成。Objective:To investigate the protective effect of Weiyanling on gastric mucosa of rats.Methods: The rats were treated with Weiyanling after receiving absolute ethanol by intragastric intubation. The pathologic changes, inflammation degree, ulcer index (UI) and ulcerous area were observed. Levels of mucosal hexosamine and PGE-2 were measured respectively.Results: Weiyanling significantly decreased UI, ulcerous area and lightened congestion, edema and necrosis (P<0.05). There was obvious significance between the treatment group and the model group in the levels of hexosamine and PGE-2 (P<0.05). Conclusion: Weiyanling had cytoprotective effects on gastric mucosa in rats. The mechanism of it might inhibit inflammatory action and increase the content of hexosamine and the combination of PGE-2.

关 键 词：胃炎灵 大鼠 胃粘膜 药理作用 炎症反应 氨基乙糖 慢性胃炎 消化性溃疡 

分 类 号：R289.5[医药卫生—方剂学] R259.733[医药卫生—中药学]