SHR、SHRsp、WKy三品系大鼠血液生化检查参数  

The Biochemistry Parameters of Blood in SHR, SHRsp and WKy

作　　者：王文[1] 孙瑞成[1] 王佩合[1] 张会东[1] 李悦[1] 张宝杰[1] 逯淑琴[1] 刘云平[1] 

机构地区：[1]中国医学科学院中国协和医科大学阜外心血管病医院心血管病研究所,北京100037

出　　处：《中国比较医学杂志》2003年第5期261-268,共8页Chinese Journal of Comparative Medicine

基　　金：国家科技部科研基础性项目 (G99-E -0 2 )

摘　　要：目的　检查了解SHR、SHRsp、WKy三品系大鼠血液生化的参数。方法　每个品系分别取年轻大鼠(12周龄 )、年老大鼠 (2 2～ 2 8周龄 )各 14只 ,心脏取血 ,用自动生化分析仪检验血生化及电解质等指标。结果　年老SHR、SHRsp、WKy大鼠血肌酐平均水平较年轻大鼠分别高 8 5 %、9 2 %和 14 2 % (P =0 0 7;P =0 0 7;P =0 0 4 ) ,但血钙、血磷较低。同龄SHR、SHRsp血磷平均水平均较同龄WKy低 2 5 0 % (P =0 12～P <0 0 0 1)。同龄SHR、SHRsp的肌酸磷酸激酶同工酶 (CK MB)及乳酸脱氢酶同工酶 (LDH 1)较WKy升高 1～ 2倍 (P =0 15～P <0 0 0 1)。结论　SHR、SHRsp及Wky三种品系大鼠的血液生化参数多为相似 ,但也有一些差别。Objective To investigate the biochemistry parameters of blood in SHR,SHRsp and WKy. Methods 14 blood samples of younger(12 weeks old) and older(22-28 weeks old)each in SHR,SHRsp and WKy were measured by auto-biochemistry analysis(SYNCHRON CX9 Clinical system ALX).Results The blood creatinine level was higher in older SHR, SHRsp and WKy than WKy in younger SHR,SHRsp and WKy. The levels of blood calcium and phosphorus were lower in older SHR,SHRsp and WKy than in their younger. The blood phosphorus level was lower in SHR, SHRsp than in WKy in same age. The levels of blood CKMB and LDH-1 were higher in SHR and SHRsp than in WKy. Conclusion Most,except some,of the biochemistry parameters in the blood of SHR, SHRsp and WKy are similar.

关 键 词：SHR SHRSP WKY 大鼠 血液生化检查 参数 自发性高血压 脑卒中 

分 类 号：R446.112[医药卫生—诊断学] R544.1[医药卫生—临床医学]