听觉诱发电位指数指导异氟醚与安氟醚麻醉的可行性  

Feasibility of auditory evoked potential index in guidi ng isoflurane or enflurane anesthesia

作　　者：孙永兴[1] 李萍[1] 宋晓丽[1] 王丽范[2] 

机构地区：[1]哈尔滨医科大学第一临床医学院麻醉科 [2]重症监护病室,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2003年第5期426-428,共3页Journal of Harbin Medical University

摘　　要：目的　观察听觉诱发电位指数 (AEP index)是否可用于指导异氟醚与安氟醚麻醉。方法　 4 0例择期手术病人 ,随机分成 4组 (n =10 ) :组Ⅰ为异氟醚指导组 (Iso t) ,组Ⅱ为异氟醚对照组 (Iso c) ,组Ⅲ为安氟醚指导组 (Enf t) ,组IV为安氟醚对照组 (Enf c)。对照组仅凭临床经验来调节异氟醚与安氟醚吸入浓度。指导组则通过维持AEP index值在 30左右来调节异氟醚与安氟醚吸入浓度。记录麻醉期间血压、心率及AEP index变化 ,并记录各麻醉药用量。结果　指导组收缩压明显高于对照组 (P <0 .0 5 ) ,且波动幅度较对照组大。对照组AEP index明显低于指导组 (P <0 .0 5 ) ,但麻醉维持过程相对较平稳 ,镇痛药与肌松药用量明显少于指导组。结论　AEP index可为异氟醚与安氟醚吸入麻醉镇静与睡眠的深度提供量化指标 ,且能预测体动 ,但尚不能完全依赖AEP index来指导麻醉。Objective To assess the feasibility of using auditory evoked pote ntial index to guide isoflurane or enflurane anesthesia. Methods Forty ASA Ⅰ-Ⅱ patients were randomly divided into four groups.Group Ⅰ:isoflurane titrating(Iso-t);group Ⅱ:isoflurane contrasting(Iso -c) ;group Ⅲ:enflurane titrating(Enf-t);group Ⅳ:enflurane contrasting(Enf-c). Anesthesia was mainatined with either isoflurane or enflurane. The volume of oxy g en was stabilized in 1.0L/min. In the control groups,the anesthesiologists were b linded to the AEP-index,and the volatile anesthetics were administered accordin g to clinical experience.In AEP-index titrated groups the volatile anesth etics were titrated to maintain the AEP-index at about 30. Results During the maintenance period,the SBP in AEP - index titra ted groups was higher than that in control groups,while SBP fluctuation was les s in control groups than that in AEP-index titrated groups. The requirements o f volatile anesthetics were lower in AEP-index titrated groups than those in con trol groups. Conclusion In spite of predicting the sedation effect and movement of body of isoflurane or enflurane,AEP-index can not guide isoflurane or enflu rane anesthesia.

关 键 词：听觉诱发电位指数 异氟醚 安氟醚 麻醉 可行性 

分 类 号：R971.2[医药卫生—药品] R614[医药卫生—药学]