老年高血压患者血浆中血管性假血友病因子和D-二聚体变化及其意义  

Changes of circulting von Willebbrand factor and D-dimer in elderly patients with essential hypertension

作　　者：李结华[1] 唐海沁[1] 刘先进[1] 徐迎春[1] 陈曙光[1] 

机构地区：[1]安徽医科大学第一附属医院干部病房,合肥230022

出　　处：《安徽医科大学学报》2003年第5期383-384,共2页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生厅科学研究基金资助课题 (编号 :2 0 0 2A0 3 6)

摘　　要：目的　通过观察原发性高血压 (EH)患者血浆中血管性假血友病因子 (VWF)及D二聚体 (D D)的变化 ,探讨其与不同严重程度高血压病患者的关系。方法　用酶联免疫吸附法测量 5 8例EH患者 (EH组 )和 2 0例正常者 (对照组 )外周血浆中VWF、D D水平变化。并对不同分级或分层的EH患者上述指标进行比较。结果　 2级、3级高血压或中危、高危、极高危EH患者血浆VWF、D D水平与对照组、1级或低危EH患者比较明显升高 (P <0 0 5 ,P <0 0 1)。而 1级或低危EH患者上述指标与对照组比较无升高 (P >0 0 5 )。结论　VWF、DObjective To study von Willebbrand factor (V WF) and D-dimer(D-D) in patients with essential hypertension(EH). Methods The levels of VWF and D-D were measured by ELISA in 58 patients with EH and 20 normal controls.All param eters were compared in the EH patients with different class and stratification. Results The concentration of VWF and D-D were significantl y higher in patients. With class 2,3 or risk, higher risk and very high ris k group than those in control group and patients with class 1 or low risk group (P<0 05, P<0 01).There was no significant difference between the patient s with class 1 or low risk group and control group(P>0 05). Co nclusion The high content of VWF and D-D is related to blood pressure a nd risk factors.

关 键 词：原发性高血压 血浆 血管性假血友病因子 D二聚体 老年人 酶联免疫吸附法 临床意义 

分 类 号：R544.1[医药卫生—心血管疾病]