聚羟基乙醇酸中锡的无火焰原子吸收测定法研究  

Determination of residual Sn level in poly L-lactic-co-glycolic acid by GF atomic absorption spectrophotmetry

作　　者：赵国琴[1] 高永清[1] 周安石 俞敏[3] 储成顶[1] 

机构地区：[1]安徽医科大学理化中心,合肥230032 [2]安徽省产品质量检验所,合肥230037 [3]合肥工业大学控释药物研究所,合肥230009

出　　处：《安徽医科大学学报》2003年第5期406-408,共3页Acta Universitatis Medicinalis Anhui

基　　金：国家科技部基础研究快速反应支持项目(编号:国科基字2 0 0 1 5 1)

摘　　要：目的　建立聚羟基乙醇酸辅料的锡 (Sn)含量测定方法。方法　样品经硫酸处理 ,干法马弗炉灰化 ,盐酸溶解 ,石墨炉原子吸收光谱法测定。抗坏血酸为基体改进剂。结果　线性范围为 1～ 10mg/L ;r =0 996 8;检出限为 0 2 3mg/L ;方法的平均回收率为 97 1% ;日内RSD为 6 9%。结论　该方法已符合 2 0 0 0年中国药典关于杂质限量检测方法的规定 。Objective To establish a method for determination of Sn in poly L-lactic-co-glycolic acid pharmaceutical necessities. Metho ds The specimen was soaked by H 2SO 4 ,incinerated by the muffle ,diss olved by HCl and determined by GF-AAS. Vitamin C was used as a matrix modifier. Results The linear range was 1～10 mg/L;r= 0 996 8 ;The limit of detection was 0 23 mg/L;The ave rage recovery was 97 1% ; The intra-day precision of method was 6 9%. Conclusion The method meets the criterion of China Pharmacopoeia 2000 fo r detecting drug impurity and is feasible for the determination of Sn in poly L-lac tic-co-glycolic acid pharmaceutical necessities.

关 键 词：聚羟基乙醇酸 锡 石墨炉原子吸收光谱法 含量测定 硫酸处理 

分 类 号：R927.2[医药卫生—药学]