阻塞性睡眠呼吸暂停低通气综合征血栓前状态研究  

Study of prethrombotic state(PTS) in patients with obstructive sleep apnea-hypopnea syndrome

作　　者：杜向阳[1] 王少媛[1] 王言森[1] 李戈阳[1] 

机构地区：[1]山东省交通医院呼吸科,济南250031

出　　处：《中国基层医药》2003年第10期983-985,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨阻塞性睡眠呼吸暂停低通气综合征 (OSAHS)病人是否存在血栓前状态。方法　选择年龄、性别、体重指数 (BMI)无明显差异的OSAHS病人 5 2例和健康者 4 8例 ,用多导睡眠呼吸监测仪进行监测 ,以Clauss法测定Fg ,以发色底物法测组织纤溶酶原激活物活性 (tPA∶A)、纤溶酶原激活物抑制物 1活性 (PAI 1∶A) ,抗凝血酶 Ⅲ活性 (AT ⅢA) ,以酶联免疫法测vonWillebrand因子 (vWF)、组织纤溶酶原激活物抗原 (tPA∶Ag)、纤溶酶原含量 (PLg∶Ag)和纤溶酶原激活物抑制物 1含量 (PAI 1∶Ag)。以免疫火箭电泳法测抗凝血酶 Ⅲ抗原 (AT ⅢAg)。 结果　OSAHS组与对照组比较vWF、Fg、PAI 1∶A、PAI 1∶Ag明显升高 (P分别 <0 0 0 1、0 0 5、0 0 1、0 0 5 ) ,AT ⅢAg、AT ⅢA、PLg∶Ag、tPA∶Ag明显降低 (P分别 <0 0 1、0 0 5、0 0 5、0 0 5 )。Objective To explore if there is prethrombotic state in patient with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods Polysomnography was performed in 52 patients with OSAHS and 48 normal controls without difference in age,sex and body mass index(BMI).Fibrinogen(Fg) was measured by Clauss assay.Tissue plasminogen activator activity(tPA∶A),plasminogen activator inhibitory-1 activity(PAI-1∶A),antithrombin-Ⅲ activity(AT-ⅢA) were measured by chromogenic substrate assay.Von willebrand factor(vWF),tissue plasminogen activator antigen(tPA∶Ag),plasminogen antigen(PLg∶Ag),plasminogen activator inhibitory-1 antigen(PAI-1∶Ag) were measured by enzyme linked immunosorbent assay(ELISA).Antithrombin-Ⅲ antigen(AT-ⅢAg) was measured by rocket electroimmuno-diffusion.Results vWF,Fg,PAI-1∶A,PAI-1∶Ag were significantly higher in patients with OSAHS than those in normal controls(P<0.001,0.05,0.01,0.05).AT-ⅢAg,AT-ⅢA,PLg∶Ag,tPA∶Ag were significantly lower in patients with OSAHS than those in normal controls(P<0.01,0.05,0.05,0.05).Conclusion There is prethrombotic state in patients with OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 血栓前状态 组织纤溶酶原激活物活性 纤溶酶原激活物抑制物-1活性 

分 类 号：R56[医药卫生—呼吸系统]