等吸收点法及K系数法同时测定复方磺胺甲噁唑两组分含量的研究  

SIMULTANEOUS DETERMINATION OF TWO COMPONENTS OF SULFAMETHOXAZOLUM COMPOSITE IN 1,4-DIOXANE BY THE METHODSOF EQUATITY-ABSORPTIVITY AND K-COEFFICIENT

作　　者：张有贤[1] 郭安城[1] 张生万[1] 宋文英[1] 郭志斌[1] 

机构地区：[1]山西大学化学系

出　　处：《山西大学学报（自然科学版）》1992年第3期266-270,共5页Journal of Shanxi University(Natural Science Edition)

基　　金：山西省自然科学基金

摘　　要：本文利用复方磺胺甲(口恶)唑中甲氧苄氨嘧啶(TMP),在二氧六环中E_2带的增色效应和紫移作用,建立了该复方片剂中磺胺甲基异(口恶)唑(SMZ)和TMP两组分的等吸收点法及K系数法同时测定的新方法。该法灵敏度、准确度均较药典法高,同时测定简单快速,特别是采用UV-265光度计的指令链功能,大大加快了测定速度。应用该法进行了市售复方片剂分析,获得满意的结果。The new methods of cquatity-absorptivity and K-coefficient spectropho-tometry have been developed for the simultaneous determination of sulfa-methoxazolum(SMZ) and trimemhoprimum(TMP) contained in Tabellae Sulfa-methoxazoli Composite. The methods take the advance of the hyperchromic effect and blue shift effect of E^2-band of TMP in 1, 4-dioxane,Using the command chain function of UV-265 spcctrophotometer,We can improve its sensitivity, accuracy, and speed of determination.The methods have been used in the analysis of commercial drug and the result is the same as that found in the pharmacopeia.

关 键 词：抗菌优 SMZ TMT 等吸收点法 K系数 

分 类 号：R978.2[医药卫生—药品]