慢性充血性心力衰竭患者血浆TNF-α、NOS活性和NO的变化及其意义  

Changes and Significance of TNF-α,NOS Activity and NO in the Plasma of Patients with Chronic Congestic Heart Failure

作　　者：周亚峰[1] 程绪杰[1] 刘志华[1] 

机构地区：[1]苏州大学附属第一医院心内科,苏州215006

出　　处：《苏州大学学报（医学版）》2003年第5期559-561,共3页Suzhou University Journal of Medical Science

摘　　要：目的　探讨肿瘤坏死因子 -α(TNF -α)、一氧化氮合酶 (NOS)活性和一氧化氮 (NO)在慢性充血性心力衰竭 (CHF)患者血浆中的变化以及三者之间的相互关系。方法　 80例CHF患者和 2 0名健康对照组抽取静脉血检测TNF -α、NOS活性和NO ;TNF -α含量测定采用放射免疫法 ,NOS活性、NO含量测定采用化学比色法。结果　CHF组的TNF -α、NOS活性、NO水平均明显高于对照组 ,且随着心衰程度的加重 ,各项指标的含量逐渐升高 ;在TNF -α、NOS活性、NO两两之间及它们与反映心功能的射血分数 (EF)值之间存在着显著的直线相关关系。结论　TNF -α、NOS、NO可能参与了心衰的发生、发展 。Objective To study changes and interrelations of TNF-α?NOS activity and NO in the plasma of patients with chronic congestic heart failure(CHF). Methods The blood samples were taken from eighty patients and twenty healthy subjects.Plasma TNF-α was measured by RIA.Plasma NOS activity and NO were assessed with colorimetric analysis. Results The level of plasma TNF-α?NOS activity and NO were significantly higher in CHF patients than that in healthy subjects and were increased with the severity of heart failure .The levels of TNF-α? NOS activity and NO showed significant relation with each other and all of them were closely related to the ejection fraction. Conclusion TNF-α? NOS activity and NO increase greatly in patients of CHF and they maybe play an important roles in the progress of CHF.They can be used as markers for the severity and prognosis of heart failure.

关 键 词：充血性心力衰竭 肿瘤坏死因子 一氧化氮合酶 一氧化氮 

分 类 号：R541.61[医药卫生—心血管疾病]