马钱子碱对大鼠海马神经元钠通道的影响  

Effect of brucine analgesia on sodium current of hippocampal neurons

作　　者：李明华[1] 张艳[1] 刘巨源[1] 

机构地区：[1]新乡医学院药理教研室,河南新乡453003

出　　处：《新乡医学院学报》2003年第6期389-392,共4页Journal of Xinxiang Medical University

基　　金：河南省科技厅立项课题 (课题号 :0 0 1170 80 2 )

摘　　要：目的　研究马钱子碱镇痛作用的机制。方法　用全细胞膜片钳技术 ,首先在大鼠海马CA1锥体神经元记录出钠电流 ,然后观察马钱子碱对钠电流的影响。结果　马钱子碱可以浓度依赖的方式可逆地抑制钠电流。ObjectiveTo study the mechanism of analgesia o f bru cine.MethodsThe sodium currents were recorded in acute dissoc iated rat Hippocampal CA1 neuron using whole cell patch clamp technique.The effe cts of Brucine on sodium currents were investigated.ResultsBr ucine could inhibit sodium currents in a concentration-dependent manner. ConclusionThe block of brucine on sodium currents may have relation w ith its analgesia.

关 键 词：马钱子碱 钠通道 海马神经元 镇痛作用 机制 大鼠 

分 类 号：R961[医药卫生—药理学] R285.5[医药卫生—药学]