阿糖腺苷治疗前后慢性乙型肝炎患者肝组织中HBsAg、HBcAg表达  

The Expression of HBsAg and HBcAg in the Liver Tissues of the Patients with Chronic Hepatitis B before and after the Treatment with Arabinosydenosine.

作　　者：孙祁岩[1] 赵伟[1] 罗婵[1] 

机构地区：[1]东南大学医学院附属南京第二医院,南京210003

出　　处：《医学理论与实践》2003年第10期1126-1127,共2页The Journal of Medical Theory and Practice

摘　　要：目的:探讨慢性乙型肝炎患者阿糖腺苷治疗后肝组织中HBsAg、HBcAg的表达。方法:选择20例慢性乙型肝炎患者(男性14例,女性6例,年龄33±4岁),静脉滴注阿糖腺苷400mg/d(1次/d)×2M。治疗前、后分别行肝穿刺活检,用免疫组织化学法(SP)检测其肝组织中HBsAg、HBcAg。结果:阿糖腺苷治疗前患者肝组织中HBsAg、HBcAg分别检出20例、18例,治疗后分别减至12例、10例。阿糖腺苷治疗前后肝组织中HBcAg比较,差异有显著意义(P<0.05):阿糖腺苷治疗前后肝组织中HBsAg比较,差异无显著意义(P>0.05)。结论:阿糖腺苷可以有效促使慢性乙型肝炎患者肝组织中HBcAg阴转。Objective: To study the expression of HBsAg and HBcAg in the liver tissues of the patients with chronic hepatitis B before and after the treatment with arabinosydenosine.Methods:Twenty patients (sex: 14 cases male,6 cases female;ages:33 ±4a)with chronic hepatitis [ HBVDNA( + ) ], HBeAg( + ) , ALT > 40U/L, SB < 50μmol/L] was treated with arabinosydenosine[400mg veno-Dribhling gd(once each day) × 2M]. Before and after the treatment, the liver of the patients were punctured for detecting HBsAg, HBcAg in the liver tissues with the immunohistochemical method(SP) .Results:There are 20 cases HBsAg positive expressing and 18 cases HBcAg positive expressing before the treatment. After the treatment,there are 12 cases HBsAg positive expressing and 10 cases HBcAg positive expressing after the treatment. Before and after the treatment of arabinosydenosine, in the liver tissues, the detected results of HBcAg was significantly different (P<0.05);But the results of HBsAg wasn't significantly different ( P>0.05) . Conclu-ston: Arabinosydenosine maybe made the HBcAg in liver tissues get negative express for patients with chronic hepatitis B.

关 键 词：阿糖腺苷 治疗 乙型肝炎 肝组织 HBSAG HBCAG 基因表达 临床资料 

分 类 号：R512.62[医药卫生—内科学] R969.4[医药卫生—临床医学]