3,3,10,10-四甲基-4,9-二氮杂十二烷-2,11-二酮肟的合成  

Synthesis of 3, 3, 10, 10-Tetramethyl-4, 9-diazadodecan-2, 11-dione Dioxime

作　　者：梁高林[1] 虞燕华[1] 陈志明[1] 

机构地区：[1]江苏省原子医学研究所核医学国家重点实验室

出　　处：《中国医药工业杂志》2003年第10期492-493,共2页Chinese Journal of Pharmaceuticals

摘　　要：Methyl-2-butene reacted with isoamyl nitrite in concentrated hydrochloric acid to obtain 2-chloro-2-methyl-3-nitrosobutane which was condensed with 1,4-butanediamine to give 3, 3, 10, 10-tetramethyl-4, 9-diazadodecan-2, 11-dione dioxime (Prognox HL91) in an overall yield of 14.5%.Methyl-2-butene reacted with isoamyl nitrite in concentrated hydrochloric acid to obtain 2-chloro-2-methyl-3-nitrosobutane which was condensed with 1,4-butanediamine to give 3, 3, 10, 10-tetramethyl-4, 9-diazadodecan-2, 11-dione dioxime (Prognox HL91) in an overall yield of 14.5%.

关 键 词：组织乏氧 诊断 心脑血管 肿瘤 3 3 10 10-四甲基-4 9-二氮杂十二烷-2 11-二酮肟 乏氧组织显像剂 合成 

分 类 号：R981.9[医药卫生—药品]