盐酸奈法唑酮片的HPLC测定  

Determination of Nefazodone Hydrochloride Tablets by HPLC

作　　者：沈卫阳[1] 王健松[1] 陈蓉[1] 王羚郦[1] 胡育筑[1] 

机构地区：[1]中国药科大学分析化学教研室,江苏南京210038

出　　处：《中国医药工业杂志》2003年第10期523-524,共2页Chinese Journal of Pharmaceuticals

摘　　要：建立了盐酸奈法唑酮片含量测定的 HPL C方法。采用 Hypersil ODS柱 ,以甲醇 - 0 .0 1mol/ L 磷酸二氢钠溶液(p H4 .0 ) -三乙胺 (78∶ 2 2∶ 0 .0 2 5 )为流动相 ,检测波长 2 5 4 nm。在 5～ 10 0 μg/ m l浓度范围内 ,峰面积与浓度线性关系良好 (r=0 .9998) ,平均回收率为 99.5 % (RSD1.0 % )。A RP-HPLC method for determination of nefazodone hydrochloride tablets was presented. The Hypersil ODS column was used, with mobile phase of methanol-0.01 mol/L sodium dihydrogen phosphate(pH 4.0)-triethylamine (78∶22∶0.025),at detection wavelength of 254 nm.It had a good li-nearity in the concentration range of 5～100 μg/ml (r0.9998).The average recovery was 99.5% with RSD of 1.0%.

关 键 词：盐酸奈法唑酮 片剂 反相高效液相色谱 含量测定 HPLC方法 抗抑郁剂 

分 类 号：R971.43[医药卫生—药品] R927.2[医药卫生—药学]