高血压病人24小时血压变异性及依那普利的干预影响  

The study of 24-hours blood pressure variability and the intervention with enalapril in essential hypertensives

作　　者：刘勇[1] 杨涛[1] 

机构地区：[1]四川省自贡市第二人民医院,四川自贡643000

出　　处：《重庆医科大学学报》2003年第5期636-638,共3页Journal of Chongqing Medical University

摘　　要：目的 :研究高血压患者 2 4小时血压变异性和依那普利的干预影响。方法 :4组对象中EHⅠ -Ⅱ期 90例 ,EHⅢ期4 2例 ,健康对照 6 0例 ,治疗组EHⅠ -Ⅱ期者 4 5例均进行 2 4小时动态血压监测并分析血压变异性 (BPV)。结果 :两组高血压各时段SBPV及MAPV ,EHⅢ期组的DBPV均大于对照组 (P <0 .0 1或 0 .0 5 ) ;EHⅢ期组比EHⅠ -Ⅱ期者各时段SBPV、DBPV、MAPV均明显增大 (P <0 .0 1或 0 .0 5 ) ;治疗组治疗前后各时段BPV无差异 (P >0 .0 5 )。结论 :高血压病人在血压平均值升高的同时 ,血压变异性 (尤其是SBPV)也明显高于正常人 ,Ⅲ期高血压病人尤其显著 ;依那普利治疗 4周降压有效以后对血压变异性无显著性影响。Objective: To study 24-hour blood pressure variability (BPV) in essential hypertensives(EH) and to observe the effects of enalapril on BPV in the patients. Methods: BPV were evaluated in 132 EH patients (EH Ⅰ-Ⅱ group 90, EH Ⅲ group 42) using ambulatory blood pressure monitoring, and compared with 60 normal controls.45 EH Ⅰ-Ⅱ patients were treated with enalapril for 4 weeks by randomized single-blind study.The BPV were measured before and after treatment. Results: The SBPV and MAPV during 24-hour period, daytime or nighttime were significantly higher both EH Ⅰ-Ⅱ and EH Ⅲ than control group ( P <0.01 or 0.05),but the DBPV was higher only in EH Ⅲ than control group( P <0.05).The SBPV,DBPV or MAPV during every interval were higher apparently in EH Ⅲ than EH Ⅰ-Ⅱ( P <0.05 or 0.01).There were no difference in BPV before and after treatment ( P >0.05).Conclusion:There was a significant increase in BPV(especially in SBPV) and in particular EH Ⅲ group than control group There was no effect in BPV with EH Ⅰ-Ⅱ group by enalapril treatment for 4 weeks.

关 键 词：原发性高血压 动态血压监测 血压变异性 依那普利 

分 类 号：R544.1[医药卫生—心血管疾病] R331.3[医药卫生—内科学]