复方萘替芬霜治疗豚鼠须癣毛癣菌及白念珠菌感染的疗效观察  

Therapeutic effects of compound naftifine cream on experimental dermatophytosis in guinea pigs

作　　者：李安荣[1] 江舟[1] 王体强[1] 毛郴[1] 

机构地区：[1]重庆医科大学临床学院药剂科,重庆400016

出　　处：《重庆医科大学学报》2003年第5期633-635,共3页Journal of Chongqing Medical University

摘　　要：目的 :观察复方萘替芬霜治疗豚鼠皮肤须癣毛癣菌及白念珠菌感染的疗效。方法 :皮肤须癣毛癣菌及白念珠菌感染的动物模型各 6 0只 ,分别分为 6组 ,分别外用 2 .5 %、1.2 5 %和 0 .6 2 5 %复方萘替芬霜剂和 0 .5 %酮康唑霜与 2 %萘替芬霜和空白赋形剂 ,治疗疗程 14天。结果 :复方萘替芬霜疗效均较酮康唑霜、茶替芬霜和空白赋形剂优 (P <0 .0 1)。结论 :复方萘替芬霜剂治疗豚鼠须癣毛癣茵及白念珠菌均有较高的疗效。Objective:To evaluate the therapeutic effects of compound naftifine cream on experimental dermatophytosis caused by trichophyton purpureatum or candida albicans.Methods:Two dermatophytosis models of 120 guinea pigs were made and divided into 6 groups( n =10) respectively.Topically 2.5%,1.25%,0.625% of compound naftifine cream and 0.5% cream ketoconazole and 2% cream naftifine and control agent were used in all laboratory animals respectively.All were used for 14days.Results:The efficacy of the compound naftifine cream in topically administered animals was better than that in the ketoconazole or nafiifine cream treatment groups ( P <0.01) respectively.Conclusion:The compound naftifine cream topically used in the treatment of dermatophytosis can be permitted.

关 键 词：萘替芬 酮康唑 须癣毛癣菌 白念珠菌 霜剂 

分 类 号：R986[医药卫生—药品]