对二氯苯致突变性的实验研究  

Experimental study on the mutagenicity of P-Dichlorobenzene

作　　者：左派欣[1] 杨卫超[1] 姜红[1] 袁树华[1] 徐颖[1] 高屹福[1] 

机构地区：[1]河北省疾病预防控制中心,石家庄市050041

出　　处：《职业与健康》2003年第10期53-55,共3页Occupation and Health

摘　　要：目的　研究对二氯苯的致突变性。方法　Ames试验用TA97、TA98、TA10 0和TA10 2菌株 ,加与不加S 9试验 (剂量设为 0 2 5、0 5、1 0、2 0、5 0mg/皿 ) ;小鼠骨髓多染红细胞微核试验 (剂量设为 10 0、2 0 0、40 0、80 0mg/kg)和小鼠睾丸细胞染色体畸变试验 (剂量设为 2 5 0、5 0 0、10 0 0mg/kg)。结果　Ames试验中各测试浓度的回变菌落数均未超过自然回变菌落数 2倍 ;小鼠骨髓多染红细胞微核试验和小鼠睾丸细胞染色体畸变试验 ,各剂量组和阴性对照组差异无显著性 (P >0 0 5 )。结论　该试验范围内 ,未见对二氯苯有致突变性。To study the mutagenicity of P-Dichlorobenzene.Strains TA97, TA98,TA100 and TA102 with or without S9 were applied to do Ames test (the doses were 0.25, 0.5, 1.0, 2.0 and 5.0 mg/kg). Also applied micronucleus assay of polychromatic erythrocytes (the doses were 100, 200, 400 and 800 mg/kg) and testicle chromosome aberration test on mice (the doses were 250, 550 and 1 000 mg/kg).Ames test showed that P-dichlorobenzene group didn't cause double increase of revertants in every bacterial strain. No significant difference was found in the micronucleus test and the chromosome aberration test.[Conclusion]P-dichlorobenzene has no mutagenic effect according to these tests.

关 键 词：对二氯苯 AMES试验 微核 染色体 致突变性 杀虫剂 杀菌剂 遗传毒性 农药 

分 类 号：R992[医药卫生—毒理学] S481.1[医药卫生—药学]