卡马西平血药浓度与抗癫痫作用及不良反应的关系  

The relationship between serum carbamazepine concentration and its antiepileptic effect and adverse reactions

作　　者：唐荣福[1] 张莉[1] 

机构地区：[1]武汉大学人民医院,430060

出　　处：《中国新药杂志》2003年第10期865-866,共2页Chinese Journal of New Drugs

摘　　要：目的:了解卡马西平血药浓度与抗癫痫作用及不良反应的关系。方法:采用荧光偏振免疫法测定52例癫痫患者卡马西平的血药浓度。结果:31例血药浓度在4～12μg·mL^(-1),抗癫痫作用有效为25例,有效率约80.6％;17例血药浓度低于4μg·mL^(-1),无1例有效;4例血药浓度高于12μg·mL^(-1),全部有效但发生了明显的不良反应。结论:卡马西平疗效及不良反应与血药浓度有关。Objective:To explore the relationship between serum carbamazepine (CBZ) concentration and its antiepileptic effect and adverse reactions. Methods : The serum CBZ concentration in 52 patients was determined by FPIA (fluorescence polarization immunoassy). Results:31 of 52 patients had a serum CBZ concentration range of 4- 12μg· mL-1 with an effective rate of 80.6% (25/31);17 of them had a serum CBZ concentration less than 4/j.g'mL with an effective rate of o% , and 4 of them had a serum CBZ concentration of more than 12μg·mL-1 with an effective rate of 100% but with obvious adverse drug reactions. Conclusion: The serum CBZ concentration is related to its antiepileptic efficacy and adverse reactions.

关 键 词：卡马西平 血药浓度 荧光偏振免疫 抗癫痫 

分 类 号：R971.6[医药卫生—药品] R749.17[医药卫生—药学]