丙泊酚对颅脑手术创伤后自由基代谢变化的影响  

Effects of propofol on free radicals level in blood after brain operation

作　　者：张良成[1] 陈百红[2] 杨庆[2] 郭永正[1] 杨锡馨[2] 

机构地区：[1]福建医科大学附属1协和医院麻醉科,福州350001 [2]第一医院麻醉科,福州350005

出　　处：《中国新药杂志》2003年第10期851-853,共3页Chinese Journal of New Drugs

基　　金：福建省教育厅科研基金(编号:JB98075)

摘　　要：目的:观察丙泊酚对颅脑手术创伤所致自由基水平变化的影响。方法:选择会侵袭脑实质的颅内手术病例,分为丙泊酚麻醉和常规麻醉2组,分别于手术前后检测血中脂质过氧化产物丙二醛(MDA)水平。结果:常规麻醉下颅脑手术后脑脊液和血浆中MDA水平显著升高(P<0.001),提示氧自由基对生物膜脂质成分的过氧化损伤作用增强;丙泊酚麻醉组血浆和脑脊液MDA水平均明显低于非丙泊酚麻醉组(P<0.05,0.01)。结论:丙泊酚具有抑制颅脑手术所致脂质过氧化反应增强的作用。Objective: To observe the effect of propofol on the changes of free radical metabolism ?induced by brain operation. Methods:Patients who will be performed brain operation were selected into the study. 25 patients were randomized to enter either a normally general anesthesia group ( n = 13) or a propofol intravenous anesthesia group ( n = 12). Blood and cerebrospinal fluid ( CSF) samples were taken for examining MDA to indicate the extent of peroxidation. Results:The MDA levels in blood and CSF after brain operation increased obviously under normally general anesthesia (P < 0. 001) ,but the increases of MDA in the propofol intravenous anesthesia group were lower significantly than that in a normally general anesthesia group (P<0.05,P<0.01). Conclusions: Propofol can inhibit the enhance of lipid peroxidation after brain operation.

关 键 词：丙泊酚 麻醉 自由基 脂质过氧化反应 

分 类 号：R971.2[医药卫生—药品] R651.1[医药卫生—药学]