缬沙坦治疗肾性高血压临床疗效观察  

CLINICAL STUDY OF VALSARTAN FOR RENAL HYPERTENTION

作　　者：王世明[1] 徐向明[1] 

机构地区：[1]临沂医专附属临沂市人民医院肾内科,山东临沂276003

出　　处：《临沂医学专科学校学报》2003年第6期461-462,共2页Journal of Linyi Medical College

摘　　要：目的 观察缬沙坦对肾性高血压的降压效果及对24h尿蛋白定量、肌酐、肌酐清除率、肝功能、电解质的影响。方法 60例肾性高血压病人口服缬沙坦80～160nmg/d治疗8周,治疗前后观察血压变化,24h尿蛋白定量,肝功能、电解质的变化。结果 缬沙坦治疗后血压明显下降,24h蛋白尿明显减少,肝功、电解质无变化。结论 缬沙坦对肾性高血压有较好的降压作用,且能降低尿蛋白,有一定的靶器官保护作用,是一种安全有效的降压药。Objective To investigate the antihypertension efficacy of valsartan and it's effects on the hepatic and renal functions,serum electrolyte,creatinine clearence and serum creatinine. Methods Sixty patients with renal hypertension were given valsartan 80-160mg per day for a course of 8 weeks. Before and after vasartan treatment, we made comparative studys of blood pressure, hepatic and renal functions and serum electrolyte. Results There was significant difference in blood pressure and the uric protein in 24h before and after vasartan treatment. Conclusion Valsartan can decrease renal hypertention and protect renal function as a safety,effective drug.

关 键 词：缬沙坦 肾性高血压 

分 类 号：R544.14[医药卫生—心血管疾病]