调肝导浊中药对体外培养大鼠主动脉平滑肌细胞C-myc,PDGF-R表达的影响  

The Influences of Modulating Liver and Eliminating Turbidity Herbs to The Expression of C-myc,PDGF-R of Rat's Aortic Smooth Muscle Cells in Vitro

作　　者：崔洪英[1] 陆一竹[1] 范英昌[1] 

机构地区：[1]天津中医学院,天津300193

出　　处：《生物医学工程研究》2003年第3期51-53,共3页Journal Of Biomedical Engineering Research

基　　金：天津市教委资助课题 ;项目编号 :9912 14

摘　　要：运用体外培养技术 ,培养大鼠主动脉SMC ,以加高脂血清和加中药等不同培养基进行分组培养 ,取细胞进行指标检测。结果表明 :调肝导浊中药可抑制SMC原癌基因C -myc及PDGF -R的表达。提示该中药可有效阻断SMC增殖的关键环节 ,从而阻止As发生发展。Using the technology of in vitro culture, we cultured smooth muscle cell of aorta and treated with high lipid serum or traditional Chinese medicine respectively in different groups to investigate effect of Modulating Liver and Eliminating Turbidity herbs on preventing proliferation of aortic smooth muscular cell of rat. Then we assayed expression of C-myc and PDGF-A of smooth muscle cell. Transfering liver lead turbid traditional Chinese medicine suppressed expression of C-myc and PDGF-R of smooth muscle cell.Results show that this traditional Chinese medicine block key link who SMC breeds effectively, thus prevent AS from taking place and developing.

关 键 词：调肝导浊中药 平滑肌细胞 血小板源生长因子 原癌基因 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]