肝素对患感染性疾病的新生儿组织因子途径抑制物影响的观察  

Observation of the Effect of Heparin on TFPI in Neonates with Infective Diseases

作　　者：李晓静[1] 蔡晓燕[1] 李晓辉[1] 包承鑫[1] 周敏[1] 李晋蜀[1] 李丹[1] 周开宇[1] 

机构地区：[1]成都市儿童医院,成都610017

出　　处：《血栓与止血学》2003年第4期156-157,181,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的:观察肝素对患感染性疾病的新生儿组织因子途径抑制物(TFPI)的影响。方法:采用酶联免疫吸附试验(ELISA)法检测了32例患感染性疾病的新生儿在使用肝素前和使用肝素后30～45分钟、6小时血浆TFPI的变化,并与患儿对照组、正常对照组及文献进行比较。结果:患儿治疗组使用肝素后30～45分钟血浆TFPI水平明显增高(t=3.953,P<0.001),6小时血浆TFPI又几乎降至用药前水平(t=0.141,P<0.05)。结论:新生儿对肝素的反应与成人不同。Objective: To observe the effect of heparin on TEPI in neonates with infective diseases. Methods: Level of plasma TFPI was detected by enzyme linked immunosorbent assay(ELISA)before and 30 - 40 min,6 h after heparin in 32 neonates with infective diseases and compared with the comtrol groups not using heparin, normal neonates and references. Results: Level of plasma TFPI was significantly higher 30 - 45 min after using heparin(t = 3. 593, P < 0.001) than that of control group, but it cpaickly decreased to the level before heparin( t = 0. 141, P < 0. 05) . Conclusion: The reaction of neonates to heparin was different from that of adult.

关 键 词：肝素 感染性疾病 新生儿 组织因子途径抑制物 检测 酶联免疫吸附试验 

分 类 号：R722.13[医药卫生—儿科] R973.2[医药卫生—临床医学]