Synthesis,Crystal Structure and Antitumor Activity of Mixed Ligand Coordination Compound of Copper with Norfloxacin and 1,10-Phen,[Cu(NFLX)(phen)(H2O)]NO3·3H2O  

作　　者：GuoPingWANG LiChengYAN LongGuanZHU 

机构地区：[1]DepartmentofChemistry,ZhejiangUniversity,Hangzhou310027 [2]DepartmentofChemistry,i-iangzhouTeachersCollege.Hanzghou310012

出　　处：《Chinese Chemical Letters》2003年第11期1182-1184,共3页中国化学快报（英文版）

基　　金：funded by the National Natural Science Foundation of China(No.50073019)

摘　　要：The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.

关 键 词：SYNTHESIS crystal structure antitumor activity NORFLOXACIN coordination compound of copper. 

分 类 号：R979.1[医药卫生—药品] R914.4[医药卫生—药学]