216例癫痫患者卡马西平血药浓度监测与合理用药  被引量:4

Monitoring the Blood Concentrations of Carbamazepine in 216 Epileptic Patients and Rational Use of Drug

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作  者:唐薇[1] 杨春梅[1] 江秀华[1] 廖淑清[1] 

机构地区:[1]昆明医学院附属第一医院药剂科,昆明市650032

出  处:《中国医院用药评价与分析》2001年第2期104-105,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘  要:目的:合理应用卡马西平。方法:采用荧光偏振免疫法对216例服用卡马西平的癫痫患者进行血药浓度监测,并观察其临床疗效。结果:单用卡马西平的患者,血药浓度在有效范围且癫痫发作得以基本控制的占60.9%,8.7%的患者血药浓度不在有效范围而癫痫发作仍得以控制;联合用药中48.2%的患者癫痫发作得以控制。结论:血药浓度监测为临床医师合理应用卡马西平提供科学依据,但必须考虑一些影响因素,如卡马西平自我诱导代谢作用,代谢物卡马西平10,11-环氧化物对临床疗效的影响,药物相互作用,以及给药频率等。AIM: To discuss the rational use of carbamazepinc.METHODS: The serum concentration of carbamazepinc was determined by fluorescence polarization immunoassay in 216 epileptic patients who were taking carbamazepine.The results and the therapeutic effect were studied .RESULTS: 60.9% of the patients taking carbamazepine alone and having blood levels of drug in effective range had their epileptic attack controlled and 8.7% of patients with blood levels of drug beyound effective range had their attack controlled, too. The attack was controlled in 48.2% of patients receiving combined drug therapy .CONCLUSION: Monitoring the serum concentration gives a scientific basis for administrating carbamazepine rationally .But it is necessary to consider some factors: the accelerated metabolism induced by itself; the therapeutic effect influenced by the metabolic substance,carbamazepine 10,11 - cycloxidejthe interaction of drugs and the times of administration.

关 键 词:癫痫 卡马西平 血药浓度 监测 合理用药 荧光偏振免疫法 

分 类 号:R971.6[医药卫生—药品] R969.3[医药卫生—药学]

 

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