头孢拉定致血尿原因分析及合理用药  

Analysis of the Factors in Causation of Cefradine-induced Hematuria

作　　者：吴激[1] 范志刚[1] 

机构地区：[1]兰州军区乌鲁木齐总医院药剂科,乌鲁木齐市830000

出　　处：《中国医院用药评价与分析》2001年第5期289-290,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨头孢拉定致血尿的原因。方法:检索《中国医学文献数据库》(1980年～2001年2月)和《药学文摘》(1990年～2000年),对患者的年龄、性别、给药途径、血尿开始时间、预后、痊愈时间分别进行统计分析。结果:查到头孢拉定致血尿的原文献18篇,共计108个病例。文献表明,儿童的肾脏尚未发育完全和静脉应用头孢拉定是造成血尿的主要原因。结论:儿童静脉慎用头孢拉定。OBJECTIVE:To analyze the factors in the causation of cefradine-induced hematuria. METHODS:The material in CHINESE BIBLIOGRAPHIC DATA BASE OF BIOLOGY & MEDICINE(from 1980 to February 2001) and PHARMACEUTICAL ABSTRACTS( 1990- 2000) was reviewed and the data were analysed on patients' age and sex, route of drug administration, beginning of hematuria, prognosis and lime of recovery. RESULTS: 18 reports on cefradine-induced hematuria(108 cases) were found, which indicated that hematuria was mainly associated with renal hypoplasia in childhood and intravenous administration of cefradine. CONCLUSION: Intravenous administration of cefradine in children should be very careful.

关 键 词：头孢拉定 血尿 原因 合理用药 头孢菌素类抗生素 

分 类 号：R978.11[医药卫生—药品] R695.8[医药卫生—药学]