中药脑肺康对实验性犬心力衰竭的影响  

The effects of Chinese tranditional medicine Nao Fei Kang on experimental heart failure

作　　者：朱明娟[1] 黄琪[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所,天津300020

出　　处：《中国心血管杂志》2000年第2期70-74,共5页Chinese Journal of Cardiovascular Medicine

基　　金：国家九五攻关资助课题 No96-906-02-16;天津市攻关资助课题 No973112910

摘　　要：目的 研究中药脑肺康对实验性心衰的影响.方法 用戊巴比妥钠诱发犬的急性心衰,采用RM-6000生理仪、电磁流量计、AP-6dG放大器和AC-601放大器测定心输出量(CO)、左室压(LVP)、左室末期舒张压(LVEDP)、±dp/dt_(max)和心电图(ECG).结果 十二指肠给脑肺康(2.5、5、10g/kg)后心输出量、左室压、+dp/dt_(max)和血压明显上升(P<0.05),与阴性对照组有明显差异(P<0.05),但左室末期舒张压下降(P<0.05).结论 脑肺康对犬急性心衰有较好的保护作用.Objective To study protective effect of Chinese tranditional medicine Nai Fei Kang(NFK) on experimental heart failure. methods Experimental acute heart failure in dogs were induced by sodium pentobarbital,The author use the methods of RM-6000 physiological instrument, electromagnetic flowmeter, AP-601G Amplifier and AC-601G Amplifer to measure the value of cardiac output (CO) ,Left ventricular pressure (LVP) , Left ventricular end diastolic pressure (LVEDP),±dp/dtmax, and ECG. Results After NFK(2. 5,5,10g/kg) was given CO、LVP、+ dp/dt and Bp in the heart failure dogs significantly elevated (P<0. 05). There were significantly difference compared to the controls(P<0. 05). But LVEDP decreased (P<0. 05). Conclusion NFK was effective on the treatment of acute heart failure in dogs.

关 键 词：中医药治疗 实验 犬 心力衰竭 脑肺康 

分 类 号：R285.5[医药卫生—中药学]