Ge132对肝损伤及升高白细胞的作用  

Effects of Ge132 on Experimental Liver Injury and White Blood Cells

作　　者：王军[1] 俞霭瑶[1] 金正均[1] 

机构地区：[1]上海第二医科大学药理教研室

出　　处：《上海第二医科大学学报》1992年第4期312-316,共5页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：本文用不同剂量的β-羧乙基锗倍半氧化物(carboxyethylgermanium sesquioxide,Ge132)100,200,400mg/kg(ⅳ)预防四氯化碳(carbon tetrachloride,CCl_4)所致的小鼠实验性肝损伤。结果表明Ge132可降低肝损伤小鼠的血清谷丙转氨酶(SGTP)及肝甘油三酯,增加肝糖元含量,并减轻肝细胞的变性与坏死。Ge132还可缩短四氯化碳肝损伤小鼠的小戊巴比妥钠的睡眠时间及延长正常小鼠戊巴比妥钠的睡眠时间。此外,Ge132单用或与化疗药物(环磷酰胺)合用均有明显剂量依赖性升高白细胞的作用。Ge132 possesses immuno-stimulating actions such as IFN-γ induction, NK cell activation, tumor inhibition and life-span prolongation, but its effects on liver injury and white blood cells had rarely been reported. In this paper, various doses of Ge132 (100, 200, 400mg/kg,ⅳ) were used to prevent experimental liver injury induced by carbon tetrachoride (CCl_4) in mice. The results indicated that Ge132 lowered the SGPT level, decreased the accumulation of triglyceride in liver and increased the glycogen content in hepatocytes. Ge132 also shortened the pentobatbital sleeping time in CCl_4, intoxicated mice while prolonged this time in normal mice. Histological examination showed that hepatic degeneration and necrosis in Ge132 pretreated mice were less sever than those in CCl_4group without pretreatment. In addition, our data also showed that Ge132 alone or combined with cyclophosphamide (CY) elevated the white blood cell level significantly in a dose-dependent manner in normal mice.

关 键 词：Ge132 肝损伤 戊巴妥钠 

分 类 号：R965[医药卫生—药理学]