大鼠Ⅲ度烫伤后异体、自体皮混合移植局部透明质酸含量的变化  

The change in hyaluronic acid(HA) in auto-and allo-skin intermingled grafting in extensive full thickness burn in rat model

作　　者：丁韧[1] 朱德安[1] 史济湘[1] 赵雁飞[2] 王莉[2] 

机构地区：[1]上海第二医科大学瑞金医院烧伤研究所,200025 [2]上海第二医科大学病理学教研室

出　　处：《中华烧伤杂志》2000年第1期43-45,共3页Chinese Journal of Burns

基　　金：国家自然科学基金!(39290700)

摘　　要：目的探讨混合移植皮片中细胞外间质的变化。方法采用放射免疫方法测定了大鼠Ⅲ度烫伤后混合移植（异体皮打洞嵌植自体皮片）后３、５、７、１４、２１、２８ ｄ自体皮区和异体皮区透明质酸的含量变化。结果移植后自体皮区和异体皮区透明质酸含量变化均是先下降后上升，但自体皮区升高早于异体皮区，在移植后第１４天（嵌植第１２天）即开始显著升高，至２８ｄ仍显著高于正常对照，而异体皮区在移植后第 ２１天才显著升高，升高幅度也无自体皮区明显。结论在植皮同时适当外用透明质酸可能更有利于移植皮区的愈合和重建。Objective To elucidate the changes in hyaluronic acid (HA) contents in auto-and alloskin intermingled grafting. Method HA was determined by rado-immunoassay in auto-and alloskin intermingled grafting (a large sheet of allograft inlaid with small stamps of autoskin) in experimental extensive full-thickness burn rats on 3rd,5th,7th, 14th,21st, 28th postoperation days. Results In both areas of intermingled skin grafting,the contents of HA was reduced first and in- creased significantly thereafter, but the contents in auto-skin areas rose earlier and higher than those in allo-ones. Conclusion The results suggest that adequate application of HA may be beneficial to the healing and remodelling of grafted area.

关 键 词：大鼠 Ⅲ度烫伤 异体皮移植 自体皮移植 混合移植 透明质酸 

分 类 号：R644[医药卫生—外科学] R622.1[医药卫生—临床医学]