410例喹诺酮类药物不良反应文献分析  

A review of adverse reactions to quinolones in 410 cases

作　　者：潘巧仪[1] 王蕾[1] 阎书凤[1] 

机构地区：[1]广州市医药卫生研究所,广州510180

出　　处：《药物不良反应杂志》2000年第1期28-30,共3页Adverse Drug Reactions Journal

摘　　要：目的:对我国人群中应用喹诺酮类药物后出现的不良反应进行总结,进行上市后药物的安全性评价。方法:采用文献计量学方法,将近5年国内有关喹诺酮类药物不良反应的临床文献报道进行收集、调查与分析。结果:调查分析表明,发生药物不良反应最多的是氟哌酸,其次是环丙沙星、吡哌酸、培氟沙星、氧氟沙星、依诺沙星;涉及临床类型较多,主要是过敏反应和神经系统症状。结论:临床医生应重视药物不良反应监测,合理用药。Objective: To review the adverse reactions induced by quinolones and make safety assessment of the drugs on the market. Methods: Clinical reports on ADR of quinolones, published during the last five years, were collected and analysed by means of literature metrology. Results: In accordance with the incidence of ADR nofloxacin ranked the first, followed by ciprofloxacin, pipemidic acid, pefloxacin, ofloxacin and enoxacin. Various clinical manifestations were involved, mostly allergic reactions and neurological symptoms. Conclusion: Physician s attention should be drawn to ADR surveillance and rational medication.

关 键 词：喹诺酮类药物 药物不良反应 抗菌药物 氟哌酸 环丙沙星 

分 类 号：R978[医药卫生—药品]