壮骨关节丸引起肝损害与费用分析  

Liver damage caused by Zhuangguguanjie Wan and cost analysis

作　　者：周颖[1] 郑桂凤[1] 

机构地区：[1]北京医科大学第一医院,北京100034

出　　处：《药物不良反应杂志》2000年第1期20-23,共4页Adverse Drug Reactions Journal

摘　　要：目的:通过对壮骨关节丸引起肝损害病例的分析,为合理用药提供参考。方法:总结近7年来本院发生的壮骨关节丸引起肝损害的病例共12例,分析肝损害的发生情况、发病时间、临床特点及消耗费用。结果:1996年以前肝损害病例多,平均服药48天后出现症状,ALT为45～1065U/L,T-BIL为21.3～376μmol/L,平均住院39.44天,平均消耗5605.36元。结论:药品管理部门应加强对该药的说明书和药品广告的管理,服药的患者应定期监测肝功能。Objective: To analyze the liver damage caused by Zhuangguguanjie Wan for providing information about rational use of the drug. Methods: Liver damage caused by Zhuangguguanjie Wan in our hospital in the last seven years was reviewed in order to analyze its incidence, time of occurrence, clinical characteristics and cost. Results: Most cases were before 1996 and symptoms appeared after 48 days of taking medicine on average. The patients' ALT were 45~1065 U/L, T-BIL were 21.3~376mol/L. The average time they were in hospital was 39.44 days and the average cost was 5605.36 yuan. Conclusion: Drug administration authorities should strengthen the management of package inserts and drug advertisement and the patient should be regularly tested for liver function when using it.

关 键 词：壮骨关节丸 肝损害 费用 药物不良反应 合理用药 

分 类 号：R286[医药卫生—中药学]